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1

Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a humanin vivoLPS infusion study

Suthesh Sivapalaratnam, Rosienne Farrugia, Max Nieuwdorp, Cordelia F Langford, Rachel T van Beem, Stephanie Maiwald, Jaap Jan Zwaginga, Arief Gusnanto, Nicholas A Watkins, Mieke D Trip, Willem H Ouweh

Journal:

BMC Medical Genomics

Year:

2011

Language:

english

File:

PDF, 237 KB

english, 2011

2

Genome-Wide Association Studies in Atherosclerosis

S. Sivapalaratnam, M. M. Motazacker, S. Maiwald, G. K. Hovingh, J. J. P. Kastelein, M. Levi, M. D. Trip, G. M. Dallinga-Thie

Journal:

Current Atherosclerosis Reports

Year:

2011

Language:

english

File:

PDF, 276 KB

english, 2011

3

More outreach for young scientists

Aalbers, Caroline J., Groen, Justus L., Sivapalaratnam, Suthesh

Journal:

Year:

2010

Language:

english

File:

PDF, 121 KB

english, 2010

4

Low-density lipoprotein receptor mutations generate synthetic genome-wide associations

Oosterveer, Daniëlla M, Versmissen, Jorie, Defesche, Joep C, Sivapalaratnam, Suthesh, Yazdanpanah, Mojgan, Mulder, Monique, van der Zee, Leonie, Uitterlinden, André G, van Duijn, Cornelia M, Hofman, A

Journal:

European Journal of Human Genetics

Year:

2012

Language:

english

File:

PDF, 198 KB

english, 2012

5

Long-term LDL-c lowering in heterozygous familial hypercholesterolemia normalizes carotid intima-media thickness

S. Sivapalaratnam, L.L. van Loendersloot, B.A. Hutten, J.J.P. Kastelein, M.D. Trip, E. de Groot

Journal:

Atherosclerosis

Year:

2010

Language:

english

File:

PDF, 175 KB

english, 2010

6

Abstract: 1024 THE DYSLIPIDEMIA OF MOTHERS WITH FAMILIAL HYPERCHOLESTEROLEMIA DETERIORATES LIPID LEVELS IN THEIR ADULT OFFSPRING

van der Graaf, A, Vissers, M, Gaudet, D, Brisson, D, Sivapalaratnam, S, Roseboom, T, Janssen, A, Kastelein, J, Hutten, B

Journal:

Atherosclerosis Supplements

Year:

2009

Language:

english

File:

PDF, 84 KB

english, 2009

7

Abstract: P213 DIFFERENTIAL MONOCYTIC GENE EXPRESSION IN SUBJECTS WITH PREMATURE MYOCARDIAL INFARCTION

Sivapalaratnam, S, Basart, H, Watkins, N, Goodall, A, Krishnan, U, Langford, C, Kastelein, J, Ouwehand, W, Trip, M

Journal:

Atherosclerosis Supplements

Year:

2009

Language:

english

File:

PDF, 87 KB

english, 2009

8

Abstract: P378 EFFECTS OF LONG-TERM LDL-C LOWERING ON ATHEROSCLEROSIS IN ADULTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

Sivapalaratnam, S, van Loendersloot, L, Hutten, B, Trip, M, Kastelein, J, de Groot, E

Journal:

Atherosclerosis Supplements

Year:

2009

Language:

english

File:

PDF, 79 KB

english, 2009

9

449 MICRORNAS 340* AND 624* ARE UPREGULATED IN PLATELETS IN PATIENTS WITH CORONARY ARTERY DISEASE

Sondermeijer, B.M., Bakker, A., Halliani, A., Maiwald, S., Sivapalaratnam, S., Mulders, T.A., de Ronde, M.W.J., Tijsen, A.J., Marquart, J.A., Moerland, P.D., Trip, M.D., Meijers, J.C.M., Creemers, E.E

Journal:

Atherosclerosis Supplements

Year:

2011

Language:

english

File:

PDF, 42 KB

english, 2011

10

773 ASYMPTOMATIC SUBJECTS WITH A POSITIVE FAMILY HISTORY FOR PREMATURE CORONARY ARTERY DISEASE BENEFIT FROM PREVENTIVE TREATMENT: A POST-HOC ANALYSIS

Mulders, T., Sivapalaratnam, S., Stroes, E., Guerci, A., Pinto-Sietsma, S.

Journal:

Atherosclerosis Supplements

Year:

2011

Language:

english

File:

PDF, 39 KB

english, 2011

11

Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci

Folkert W. Asselbergs, Yiran Guo, Erik P.A. van Iperen, Suthesh Sivapalaratnam, Vinicius Tragante, Matthew B. Lanktree, Leslie A. Lange, Berta Almoguera, Yolande E. Appelman, John Barnard, Jens Baumer

Journal:

The American Journal of Human Genetics

Year:

2012

Language:

english

File:

PDF, 681 KB

english, 2012

12

Asymptomatic Individuals With a Positive Family History for Premature Coronary Artery Disease and Elevated Coronary Calcium Scores Benefit From Statin Treatment: A Post Hoc Analysis From the St. Francis Heart Study

Ties A. Mulders, Suthesh Sivapalaratnam, Erik S.G. Stroes, John J.P. Kastelein, Alan D. Guerci, Sara-Joan Pinto-Sietsma

Journal:

Journal of the American College of Cardiology: Cardiovascular Imaging

Year:

2012

Language:

english

File:

PDF, 901 KB

english, 2012

13

Abnormal hemostatic parameters in patients with myocardial infarction but angiographically normal coronary arteries

Maiwald, S., Oey, R.C., Sivapalaratnam, S., Bakhtiari, K., Hovingh, G.K., Basart, D.C.G., Trip, M.D., Dallinga-Thie, G.M.

Journal:

International Journal of Cardiology

Year:

2014

Language:

english

File:

PDF, 171 KB

english, 2014

14

Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study

Sivapalaratnam, S., Boekholdt, S. M., Trip, M. D., Sandhu, M. S., Luben, R., Kastelein, J. J. P., Wareham, N. J., Khaw, K.-T.

Journal:

Heart (BMJ Pub. Group)

Year:

2010

Language:

english

File:

PDF, 219 KB

english, 2010

15

Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia

Stitziel, N. O., Fouchier, S. W., Sjouke, B., Peloso, G. M., Moscoso, A. M., Auer, P. L., Goel, A., Gigante, B., Barnes, T. A., Melander, O., Orho-Melander, M., Duga, S., Sivapalaratnam, S., Nikpay, M

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

2013

Language:

english

File:

PDF, 1015 KB

english, 2013

16

Common genetic variants do not associate with CAD in familial hypercholesterolemia

van Iperen, Erik P A, Sivapalaratnam, Suthesh, Boekholdt, S Matthijs, Hovingh, G Kees, Maiwald, Stephanie, Tanck, Michael W, Soranzo, Nicole, Stephens, Jonathan C, Sambrook, Jennifer G, Levi, Marcel,

Journal:

European Journal of Human Genetics

Year:

2014

Language:

english

File:

PDF, 320 KB

english, 2014

17

Hemostatic abnormalities in critically ill patients

Levi, Marcel, Sivapalaratnam, Suthesh

Journal:

Internal and Emergency Medicine

Year:

2015

Language:

english

File:

PDF, 452 KB

english, 2015

18

Monocyte gene expression and coronary artery disease

Maiwald, Stephanie, Zwetsloot, Peter-Paul, Sivapalaratnam, Suthesh, Dallinga-Thie, Geesje M.

Journal:

Current Opinion in Clinical Nutrition & Metabolic Care

Year:

2013

Language:

english

File:

PDF, 242 KB

english, 2013

19

Dyslipidemia of Mothers With Familial Hypercholesterolemia Deteriorates Lipids in Adult Offspring

van der Graaf, A., Vissers, M. N., Gaudet, D., Brisson, D., Sivapalaratnam, S., Roseboom, T. J., Jansen, A. C. M., Kastelein, J. J. P., Hutten, B. A.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

2010

Language:

english

File:

PDF, 536 KB

english, 2010

20

The Impact of Partial and Complete Loss-of-Function Mutations in Endothelial Lipase on High-Density Lipoprotein Levels and Functionality in Humans

Singaraja, R. R., Sivapalaratnam, S., Hovingh, K., Dube, M.-P., Castro-Perez, J., Collins, H. L., Adelman, S. J., Riwanto, M., Manz, J., Hubbard, B., Tietjen, I., Wong, K., Mitnaul, L. J., van Heek, M

Journal:

Circulation Cardiovascular Genetics

Year:

2013

Language:

english

File:

PDF, 832 KB

english, 2013

21

A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis

Maiwald, Stephanie, Motazacker, Mahdi M, van Capelleveen, Julian C, Sivapalaratnam, Suthesh, van der Wal, Allard C, van der Loos, Chris, Kastelein, John J P, Ouwehand, Willem H, Hovingh, G Kees, Trip,

Journal:

European Journal of Human Genetics

Year:

2015

Language:

english

File:

PDF, 1.55 MB

english, 2015

22

Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits

Paul, Dirk S., Nisbet, James P., Yang, Tsun-Po, Meacham, Stuart, Rendon, Augusto, Hautaviita, Katta, Tallila, Jonna, White, Jacqui, Tijssen, Marloes R., Sivapalaratnam, Suthesh, Basart, Hanneke, Trip,

Journal:

Year:

2011

Language:

english

File:

PDF, 992 KB

english, 2011

23

The Authors' reply

Sivapalaratnam, S., Boekholdt, S. M.

Journal:

Heart (BMJ Pub. Group)

Year:

2011

Language:

english

File:

PDF, 51 KB

english, 2011

24

Family history of premature cardiovascular disease as risk factor for recurrent coronary artery disease: a retrospective cohort study

Mulders, T. A., Barsom, E., Ayada, I., Sivapalaratnam, S., De Winter, R., Koch, K., Kastelein, J. J. P., Trip, M. D., Stroes, E. S. G., Pinto-Sietsma, S. J.

Journal:

European Heart Journal

Year:

2013

Language:

english

File:

PDF, 196 KB

english, 2013

25

Genetic analysis of emerging risk factors in coronary artery disease

van Iperen, Erik P.A., Sivapalaratnam, Suthesh, Holmes, Michael V., Hovingh, G. Kees, Zwinderman, Aeilko H., Asselbergs, Folkert W.

Journal:

Atherosclerosis

Year:

2016

Language:

english

File:

PDF, 303 KB

english, 2016

26

Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia

Sivapalaratnam, Suthesh, Westbury, Sarah K., Stephens, Jonathan C., Greene, Daniel, Downes, Kate, Kelly, Anne M., Lentaigne, Claire, Astle, William J., Huizinga, Eric G., Nurden, Paquita, Papadia, Sof

Journal:

Year:

2017

Language:

english

File:

PDF, 1.69 MB

english, 2017

27

Diagnosis of inherited bleeding disorders in the genomic era

Sivapalaratnam, Suthesh, Collins, Janine, Gomez, Keith

Journal:

British Journal of Haematology

Year:

2017

Language:

english

File:

PDF, 820 KB

english, 2017

28

Disseminated intravascular coagulation: an update on pathogenesis and diagnosis

Levi, Marcel, Sivapalaratnam, Suthesh

Journal:

Expert Review of Hematology

Year:

2018

Language:

english

File:

PDF, 920 KB

english, 2018

29

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

Geffen, Johanna P. van, Brouns, Sanne L.N., Batista, Joana, McKinney, Harriet, Kempster, Carly, Nagy, Magdolna, Sivapalaratnam, Suthesh, Baaten, Constance C. F. M. J., Bourry, Nikki, Frontini, Mattia,

Journal:

Year:

2018

Language:

english

File:

PDF, 3.63 MB

english, 2018

30

Germline mutations in the transcription factor IKZF5 cause thrombocytopenia

Lentaigne, Claire, Greene, Daniel, Sivapalaratnam, Suthesh, Favier, Remi, Seyres, Denis, Thys, Chantal, Grassi, Luigi, Mangles, Sarah, Sibson, Keith, Stubbs, Matthew James, Burden, Frances, Bordet, Je

Journal:

Year:

2019

Language:

english

File:

PDF, 2.90 MB

english, 2019

31

Coagulation and anticoagulation in the intraoperative setting

Levi, Marcel, Sivapalaratnam, Suthesh

Journal:

Transfusion and Apheresis Science

Year:

2019

Language:

english

File:

PDF, 421 KB

english, 2019

32

Treatment of post‐transfusion hyperhaemolysis syndrome in Sickle Cell Disease with the anti‐IL6R humanised monoclonal antibody Tocilizumab

Sivapalaratnam, Suthesh, Linpower, Lisa, Sirigireddy, Bala, Agapidou, Alexandra, Jain, Susan, Win, Nay, Tsitsikas, Dimitris A.

Journal:

British Journal of Haematology

Year:

2019

Language:

english

File:

PDF, 429 KB

english, 2019

33

A novel variant causing α2 antiplasmin deficiency: case report and experience in a UK centre

Akay, Melek, Zaidi, Abbas, Vaidya, Sujit, Sivapalaratnam, Suthesh, Theodoulou, Angela, Platton, Sean, Hart, Daniel, Pasi, John, Bowles, Louise

Journal:

British Journal of Haematology

Year:

2019

Language:

english

File:

PDF, 410 KB

english, 2019

34

A novel variant causing α2 antiplasmin deficiency: case report and experience in a UK centre

Akay, Melek, Zaidi, Abbas, Vaidya, Sujit, Sivapalaratnam, Suthesh, Theodoulou, Angela, Platton, Sean, Hart, Daniel, Pasi, John, Bowles, Louise

Journal:

British Journal of Haematology

Year:

2019

File:

PDF, 410 KB

2019

35

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

Chan, Melissa V, Hayman, Melissa A, Sivapalaratnam, Suthesh, Crescente, Marilena, Allan, Harriet E, Edin, Matthew L, Zeldin, Darryl C, Milne, Ginger L, Stephens, Jonathan, Greene, Daniel, Hanif, Moghe

Journal:

Year:

2020

File:

PDF, 1.14 MB

2020

36

Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19

Bowles, Louise, Platton, Sean, Yartey, Nada, Dave, Minal, Lee, Kurtis, Hart, Daniel P., MacDonald, Vickie, Green, Laura, Sivapalaratnam, Suthesh, Pasi, K. John, MacCallum, Peter

Journal:

New England Journal of Medicine

Year:

2020

File:

PDF, 287 KB

2020

37

An overview of thrombotic complications of old and new anticancer drugs

Levi, Marcel, Sivapalaratnam, Suthesh

Journal:

Thrombosis Research

Year:

2020

File:

PDF, 287 KB

2020